Paolo De Coppi is also an Honorary Professor at the Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, US; and at the Division Woman and Child, University Hospitals KU Leuven, Leuven, Belgium.

He has a special interest in congenital malformation and their treatment using minimally invasive techniques. He has focused his research interests on stem cells and tissue engineering, trying to find new modalities for the treatment of complex congenital anomalies. He identified a new source of cells for therapeutic applications showing the possibility of using stem cells from amniotic fluid (cover Nature Biotechnology January 2007). More recently, he has described methods to decellularised several organs and tissue such as the intestine, liver, pancreas, kidney and lung. In 2010 he was part of the team that performed the first successful transplantation of a tissue-engineered trachea on a child at the Great Ormond Street Hospital (Lancet, 2012). Recently he has developed innovative methodologies to utilise xenogeneic tissue for transplantation using decellularised pig tissue for human compatible tissue engineered oesophagus (PNAS, 2013). For his research he has received funding from MRC, NIHR, Wellcome Trust and the EU programme Horizon 2020.

He has published more than 250 peer-reviewed articles in journals such as The Lancet, Nature Biotechnology, Nature Communications, PNAS, Blood and Stem Cells; supervised more than 30 research fellow and Ph.D. students; and has been awarded various national and international grants in excess of £23 million. He is on the editorial boards of Stem Cell Development, Journal of Pediatric Surgery, Pediatric Surgery International, and Fetal and Maternal Medicine Review. As of 2011 he has been the senior associate editor for Stem Cell Translational Medicine.