TBX22 Mouse Model This research looked specifically at a gene called TBX22 that regulates important development events during normal palate formation. When defective this gene causes cleft palate, mainly in boys. Studying the effect of this gene in mice has provided significant insights as it closely mimics human palate closure. The CLEFT funded study has shown that in mice with clefts, the closure of the palate can be potentially modified or augmented by growth factors or stem cells. The potential benefit for patients is the possible identification of the causes of cleft palate as well as the possible prevention.